Full Professor
Selected Publications
Assistant Professor
H. D. Preschel, R. T. Otte, Y. Zhuo, R. E. Ruscoe, A. J. Burke, R. Kellerhals, B. Horst, S. Hennig, E. Janssen, A. P. Green, N. J. Turner, E. Ruijter* Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir. J. Org. Chem. 2023, 88, 12565–12571.
B. Horst, D. S. Verdoorn, S. Hennig, G. van der Heijden, E. Ruijter,* Enantioselective Total Synthesis of (–)-Limaspermidine and (–)-Kopsinine by a Nitroaryl Transfer Cascade Strategy. Angew. Chem. Int. Ed. 2022, 61, e202210592. DOI: 10.1002/anie.202210592
M. Faltracco, E. Ruijter*, Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine, Org. Biomol. Chem. 2021, 19, 9641–9644.
DOI: 10.1039/D1OB01966J
M. Faltracco, K. N. A. van de Vrande, M. Dijkstra, J. M. Saya, T. A. Hamlin, E. Ruijter*, Pd‐Catalyzed Cascade to Benzoxepins by Using Vinyl‐Substituted Donor‐Acceptor Cyclopropanes, Angew. Chem. Int. Ed. 2021, 60, 14410–14414. DOI: 10.1002/anie.202102862
M. Faltracco, S. Ortega-Rosales, E. Janssen, R. C. Cioc, C. M. L. Vande Velde, E. Ruijter*, Synthesis of Carbazoles by a Diverted Bischler–Napieralski Cascade Reaction, Org. Lett. 2021, 23, 3100–3104.
Braun, J.; Ariëns, M.I.; Matsuo, B.T.; de Vries, S.; van Wordragen, E.D.H.; Ellenbroek, B.D.; Vande Velde, C.M.L.; Orru, R.V.A.; Ruijter, E.*, Stereoselective Synthesis of Fused Vinylcyclopropanes by Intramolecular Tsuji-Trost Cascade Cyclization, Org. Lett. 2018, 20, 6611–6615. DOI: 10.1021/acs.orglett.8b02232
Saya, J.M.; Oppelaar, B.; Cioc, R.C., van der Heijden, G.; Vandevelde, C.M.L.; Orru, R.V.A.; Ruijter, E.*, Synthesis of polycyclic spiroindolines by highly diastereoselective interrupted Ugi cascade reactions of 3-(2-isocyanoethyl)indoles, Chem. Commun. 2016, 52, 12482–12485. DOI: 10.1039/C6CC07459F
Saya, J. M.; Roose, T.R.; Peek, J.J.; de Waal, T.J.S., van de Velde, C.M.L.; Orru, R.V.A.; Ruijter, E.*, Iodospirocyclization of tryptamine-derived isocyanides: formal total synthesis of aspidofractinine, Angew. Chem. Int. Ed. 2018, 57, 15232–15236. DOI: 10.1002/anie.201809678
van der Heijden, G.; Jong, J.A.W.; Ruijter, E.*; Orru R.V.A., 2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry, Org. Lett. 2016, 18, 984–987.
de Graaff, C.; Bensch, L.; Boersma, S.J.; Cioc, R.C.; van Lint, M.J.; Janssen, E.; Turner, N.J.; Orru, R.V.A.; Ruijter, E.*, Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction, Angew. Chem. Int. Ed. 2015, 54, 14133–14136.